Corresponding symptoms
The corneal epithelium is edematous and loses its luster. There is one or several large bullae protruding (mostly reaching several millimeters). The bullae are filled with slightly turbid liquid. Due to the mutual friction with the eyelid during blinking, the large bullae can rupture. At this time, because the corneal nerves are exposed, the patient experiences severe irritating symptoms such as pain, photophobia, and tearing. The ruptured large bullae form epithelial defects or filamentary keratitis. The large bullae can reappear and rupture repeatedly, and eventually end with the ingrowth of blood vessels to form a degenerative pannus.
Therapeutic principle
Induce human induced pluripotent stem (iPS) cells to differentiate into corneal endothelial cells
The changes in cell morphology during the process of inducing human iPS cells to differentiate into corneal endothelial cells
Pipeline progress
